منابع مشابه
Temperature-sensitive cell-lethal mutants of drosophila: isolation and characterization.
One hundred and twenty-one sensitive (ts) sex-linked lethals were screened by means of X-ray-induced somatic crossing over to determine if any were ts cell-lethal mutants. Cell-lethal mutations were identified by their ability to block the development of homozygous clones when raised under restrictive conditions (29degrees). Twenty-two ts cell-lethal mutants were isolated and categorized into t...
متن کاملHistone acetylation and gene expression analysis of sex lethal mutants in Drosophila.
The evolution of sex determination mechanisms is often accompanied by reduction in dosage of genes on a whole chromosome. Under these circumstances, negatively acting regulatory genes would tend to double the expression of the genome, which produces compensation of the single-sex chromosome and increases autosomal gene expression. Previous work has suggested that to reduce the autosomal express...
متن کاملA method for fate mapping the foci of lethal and behavioral mutants in Drosophila melanogaster.
A new method of mosaic fate mapping, called focusing, is introduced. Its advantages are that it allows a mapping, on the blastoderm surface, of the site of action of functions defined by either pre-adult lethal or behavioral mutations. Moreover, it does not require that the mosaics used be 50% of one genotype and 50% of the other. Methods for quantitative evaluation of the results of focusing, ...
متن کاملMolecular analysis of even-skipped mutants in Drosophila development.
The homeo box gene even-skipped (eve) plays a key role in the regulation of the Drosophila segmentation pattern. eve- embryos lack segment borders and show altered activities of several segmentation genes, including fushi tarazu (ftz), engrailed (en), and wingless (wg). Here, we present evidence that eve influences its own expression in a tissue-specific manner. Each of four different eve mutat...
متن کاملMutual correction of faulty PCNA subunits in temperature-sensitive lethal mus209 mutants of Drosophila melanogaster.
Proliferating cell nuclear antigen (PCNA) functions in DNA replication as a processivity factor for polymerases delta and epsilon, and in multiple DNA repair processes. We describe two temperature-sensitive lethal alleles (mus209(B1) and mus209(2735)) of the Drosophila PCNA gene that, at temperatures permissive for growth, result in hypersensitivity to DNA-damaging agents, suppression of positi...
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ژورنال
عنوان ژورنال: Nature
سال: 1974
ISSN: 0028-0836,1476-4687
DOI: 10.1038/249514c0